Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Vascular dementia is one of the most common causes of dementia after Alzheimer's
disease, causing around 15% of cases. However, unlike Alzheimer's disease, there are no …

Cholesterol is an indispensable component of the cell membrane and plays vital roles in
critical physiological processes. Brain cholesterol accounts for a large portion of total …

A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …

Aims As the potential impact of statins on cognitive decline and dementia is still debated, we
conducted a meta-analysis of observational studies to examine the effect of statin use on the …

More than 25 million people in the world today are affected by dementia, most suffering from
Alzheimer's disease. In both developed and developing nations, Alzheimer's disease has …

Alzheimer's disease is the most common cause of dementia. Research advances have
enabled detailed understanding of the molecular pathogenesis of the hallmarks of the …

In 1907, Alois Alzheimer described the case of a 51 year old woman who presented with a
relatively rapidly deteriorating memory along with psychiatric disturbances. She died four …

Background This is an update of a Cochrane review first published in 2001. At that stage
there was insufficient evidence to recommend statins for the prevention of Alzheimer's …

Cholesterol is a major constituent of the human brain, and the brain is the most cholesterol‐
rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain …