RNA interference (RNAi) quietly crept into biological research in the 1990s when
unexpected gene-silencing phenomena in plants and flatworms first perplexed scientists …

Acute bee paralysis virus (ABPV), Kashmir bee virus (KBV) and Israeli acute paralysis virus
(IAPV) are part of a complex of closely related viruses from the Family Dicistroviridae. These …

Liming Zhang, Zhuoxuan Lu, Qinghuan Zhao, Jie Huang, He Shen, and Zhijun Zhang* or
double-stranded RNA (dsRNA) via the aforementioned physisorption method onto GO,[6d] …

Topical application of nucleic acids offers many potential therapeutic advantages for
suppressing genes in the skin, and potentially for systemic gene delivery. However, the …

Instability and inadequate biodistribution of double-stranded RNA are major drawbacks to
the clinical use of RNA interference. This work compares chemical modification and …

Single-walled carbon nanotubes (SWNTs) are special nano-materials which exhibit
interesting physical and chemical properties, presenting new opportunities for biomedical …

Polyplexes between siRNA and poly (ethylene imine)(PEI) derivatives are promising
nonviral carriers for siRNA. The polyplex stability is of critical importance for efficient siRNA …

Low efficiency, significant toxicity, polymer polydispersity and poorly understood delivery
mechanisms have initially plagued the field of polymer-based gene therapy. Numerous …

Filtration surgery is the standard invasive procedure for the management of intraocular
pressure in advanced glaucoma. The key to a successful outcome is to modulate the normal …

RNA interference (RNAi) as a mechanism to selectively silence messenger mRNA (mRNA)
expression has revolutionized the biological sciences. With the identification and …