The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …

The tripartite-motif (TRIM) family represents one of the largest classes of putative single
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …

Background Intratumoral heterogeneity is the primary challenge in the treatment of
glioblastoma (GBM). The presence of glioma stem cells (GSCs) and their conversion …

Tripartite motif-containing protein 21 (TRIM21) is well known to be involved in innate
immunity, systemic lupus erythematosus and Sjögren's syndrome. In addition, TRIM21 …

Post-transcriptional regulation of gene expression plays a major role in determining the
cellular proteome in health and disease. Post-transcriptional control mechanisms are …

Molecular biomarkers combined with histopathological examination are of critical
importance in the diagnosis and treatment of gliomas. Although recent studies have shown …

Abstract mRNA export, translation, splicing, cleavage or capping determine mRNA stability,
which represents one of the primary aspects regulating gene expression and function. RNA …

Breast cancer is the most common female malignancy, but the mechanisms regulating gene
expression leading to its development are complex. In recent years, as epigenetic research …

The germinal centre (GC) is required for the generation of high affinity antibodies and
immunological memory. Here we show that the RNA binding protein HuR has an essential …

Expression of the E3 ligase TRIM21 is increased in a broad spectrum of cancers; however,
the functionally relevant molecular pathway targeted by TRIM21 overexpression remains …