Low-voltage fast (LVF) and hypersynchronous (HYP) patterns are the seizure-onset patterns
most frequently observed in intracranial EEG recordings from mesial temporal lobe epilepsy …

Seizures are complex pathological network events characterized by excessive and
hypersynchronized activity of neurons, including a highly diverse population of GABAergic …

Epileptic seizures are characterized by periods of hypersynchronous, hyperexcitability within
brain networks. Most seizures involve two stages: an initial tonic phase, followed by a longer …

Antifibrinolytic drugs are widely used to reduce blood loss during surgery. One serious
adverse effect of these drugs is convulsive seizures; however, the mechanisms underlying …

Key points In focal epilepsy the propagation of seizure discharges arising at restricted brain
sites is opposed by feedforward inhibition. Failure of this inhibition marks focal seizure …

Recurrent seizures, which define epilepsy, are transient abnormalities in the electrical
activity of the brain. The mechanistic basis of seizure initiation, and the contribution of …

Seizures in temporal lobe epilepsy can be classified as hypersynchronous and low‐voltage
fast according to their onset patterns. Experimental evidence suggests that low‐voltage fast …

Inhibitory synaptic mechanisms oppose epileptic network activity in the brain. The
breakdown in this inhibitory restraint and propagation of seizure activity has been linked to …

The sparse activity of hippocampal dentate gyrus (DG) granule cells (GCs) is thought to be
critical for cognition and behavior, whereas excessive DG activity may contribute to …

Status epilepticus is defined as a state of unrelenting seizure activity. Generalized
convulsive status epilepticus is associated with a rapidly rising mortality rate, and thus …