The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

Hundreds of microRNAs (miRNAs) are expressed in distinct spatial and temporal patterns
during embryonic and postnatal mouse development. The loss of all miRNAs through the …

INTRODUCTION The cerebral cortex is a cellularly heterogeneous structure whose
neuronal circuits underlie high-order cognitive and sensorimotor information processing …

Research on RNA-associated interactions has exploded in recent years, and increasing
numbers of studies are not limited to RNA–RNA and RNA–protein interactions but also …

Abstract Layer 4 (L4) of mammalian neocortex plays a crucial role in cortical information
processing, yet a complete census of its cell types and connectivity remains elusive. Using …

The cerebral cortex is at the core of brain functions that are thought to be particularly
developed in the human species. Human cortex specificities stem from divergent features of …

Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …

With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we
witness the RNAi therapy field reaching a critical turning point, when further improvements in …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Alzheimer's disease (AD) and cancer have inverse relationship in many aspects. Some
tumor suppressors, including miR‐34c, are decreased in cancer but increased in AD. The …