The Fanconi anaemia pathway repairs DNA interstrand crosslinks (ICLs) in the genome. Our
understanding of this complex pathway is still evolving, as new components continue to be …

The past 15 years have seen an explosion in our understanding of how cells replicate
damaged DNA and how this can lead to mutagenesis. The Y-family DNA polymerases lie at …

Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

Y-Family DNA polymerases specialize in translesion synthesis, bypassing damaged bases
that would otherwise block the normal progression of replication forks. Y-Family …

Abstract XPC recognizes UV-induced DNA lesions and initiates their removal by nucleotide
excision repair (NER). Damage recognition in NER is tightly controlled by ubiquitin and …

Gold nanoparticles (AuNPs) are an attractive delivery vector in biomedicine because of their
low toxicity and unique electronic and chemical properties. AuNP bioconjugates can be …

DNA synthesis across lesions during genomic replication requires concerted actions of
specialized DNA polymerases in a potentially mutagenic process known as translesion …

Bifunctional alkylating and platinum based drugs are chemotherapeutic agents used to treat
cancer. These agents induce DNA adducts via formation of intrastrand or interstrand (ICL) …

It has been two decades since the discovery of the most mutagenic human DNA
polymerase, polymerase iota (Polι). Since then, the biochemical activity of this translesion …

Post-translational modification by ubiquitin (ubiquitination, ubiquitylation, ubiquitinylation) is
used as a robust signaling mechanism in a variety of processes that are essential for cell …