Imaging mass spectrometry (IMS) enables highly multiplexed, untargeted tissue mapping for
a broad range of molecular classes, facilitating in situ biological discovery. Yet, challenges …

The glomerulus is a multicellular functional tissue unit (FTU) of the nephron that is
responsible for blood filtration. Each glomerulus contains multiple substructures and cell …

Introduction Spatial biology is an emerging interdisciplinary field facilitating biological
discoveries through the use of spatial omics technologies. Recent advancements in spatial …

We discuss the design, development, and evaluation of an Orbitrap/time-of-flight (TOF) mass
spectrometry (MS)-based instrument with integrated UV photodissociation (UVPD) and …

In this work, we demonstrate rapid, high spatial, and high spectral resolution imaging of
intact proteins by matrix-assisted laser desorption/ionization (MALDI) imaging mass …

Although ubiquitously present, information on the function of complex N-glycan
posttranslational modification in plants is very limited and is often neglected. In this work, we …

MALDI imaging allows for the near-cellular profiling of proteoforms directly from microbial,
plant, and mammalian samples. Despite detecting hundreds of proteoforms, identification of …

Simple Summary Post-translational O-glycosylation of proteins with N-acetylglucosamine
serves as a cellular regulator that has been linked to cancer. This sugar's variability is …

An increasing number of spatial multiomic workflows have recently been developed. Some
of these approaches have leveraged initial mass spectrometry imaging (MSI)-based spatial …

Identification of potential therapeutic candidates can be expedited by integrating
computational modeling with domain aware machine learning (ML) models followed by …