Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer
The HIV-1 envelope glycoprotein (Env) trimer contains the receptor binding sites and
membrane fusion machinery that introduce the viral genome into the host cell. As the only …
membrane fusion machinery that introduce the viral genome into the host cell. As the only …
Crystal structure of a soluble cleaved HIV-1 envelope trimer
HIV-1 entry into CD4+ target cells is mediated by cleaved envelope glycoprotein (Env)
trimers that have been challenging to characterize structurally. Here, we describe the crystal …
trimers that have been challenging to characterize structurally. Here, we describe the crystal …
Novel CD4-based bispecific chimeric antigen receptor designed for enhanced anti-HIV potency and absence of HIV entry receptor activity
Adoptive transfer of CD8 T cells genetically engineered to express “chimeric antigen
receptors”(CARs) represents a potential approach toward an HIV infection “functional cure” …
receptors”(CARs) represents a potential approach toward an HIV infection “functional cure” …
Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
Background The trimeric envelope glycoproteins (Env) on the surface of HIV-1 virions are
the targets for neutralizing antibodies (NAbs). No candidate HIV-1 immunogen has yet …
the targets for neutralizing antibodies (NAbs). No candidate HIV-1 immunogen has yet …
Role of HIV-1 envelope glycoproteins conformation and accessory proteins on ADCC responses
The role of antibody Fc-mediated effector functions in controlling or preventing infections by
human immunodeficiency type 1 (HIV-1) and simian immunodeficiency (SIV) viruses has …
human immunodeficiency type 1 (HIV-1) and simian immunodeficiency (SIV) viruses has …
Small-molecule HIV-1 entry inhibitors targeting the epitopes of broadly neutralizing antibodies
Highly active antiretroviral therapy currently used for HIV/AIDS has significantly increased
the life expectancy of HIV-infected individuals. It has also improved the quality of life …
the life expectancy of HIV-infected individuals. It has also improved the quality of life …
Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization
The third variable (V3) loop on the human immunodeficiency virus 1 (HIV-1) envelope
glycoprotein trimer is indispensable for virus cell entry. Conformational masking of V3 within …
glycoprotein trimer is indispensable for virus cell entry. Conformational masking of V3 within …
Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein
We describe methods to improve the properties of soluble, cleaved gp140 trimers of the
human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) for use in …
human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) for use in …
Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers
Human immunodeficiency virus type 1 (HIV-1) infection is a significant global public health
problem for which development of an effective prophylactic vaccine remains a high scientific …
problem for which development of an effective prophylactic vaccine remains a high scientific …
Bispecific chimeric antigen receptors targeting the CD4 binding site and high-mannose Glycans of gp120 optimized for anti–human immunodeficiency virus potency …
MH Ghanem, S Bolivar-Wagers, B Dey, A Hajduczki… - Cytotherapy, 2018 - Elsevier
Background aims Chimeric antigen receptors (CARs) offer great potential toward a
functional cure of human immunodeficiency virus (HIV) infection. To achieve the necessary …
functional cure of human immunodeficiency virus (HIV) infection. To achieve the necessary …