SARS-CoV-2 omicron BA. 5 and XBB variants have increased neurotropic potential over BA. 1 in K18-hACE2 mice and human brain organoids
The reduced pathogenicity of the omicron BA. 1 sub-lineage compared to earlier variants is
well described, although whether such attenuation is retained for later variants like BA. 5 …
well described, although whether such attenuation is retained for later variants like BA. 5 …
[HTML][HTML] Boosting with variant-matched adenovirus-based vaccines promotes neutralizing antibody responses against SARS-CoV-2 Omicron sublineages in mice
Global spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron
subvariants, such as BA. 4, BA. 5 and XBB. 1.5, has been leading the recent wave of …
subvariants, such as BA. 4, BA. 5 and XBB. 1.5, has been leading the recent wave of …
Mucosal adenoviral-vectored vaccine boosting durably prevents XBB. 1.16 Infection in Nonhuman Primates
M Gagne, BJ Flynn, SF Andrew, DR Flebbe… - BioRxiv, 2023 - biorxiv.org
Waning immunity and continued virus evolution have limited the durability of protection from
symptomatic infection mediated by intramuscularly (IM)-delivered mRNA vaccines against …
symptomatic infection mediated by intramuscularly (IM)-delivered mRNA vaccines against …
[HTML][HTML] Immunoglobulin replacement products protect against SARS-CoV-2 infection in vivo despite poor neutralizing activity
O Zimmerman, AMA Doss, B Ying, CY Liang… - JCI insight, 2024 - ncbi.nlm.nih.gov
Immunoglobulin (IG) replacement products are used routinely in patients with immune
deficiency and other immune dysregulation disorders who have poor responses to …
deficiency and other immune dysregulation disorders who have poor responses to …
[HTML][HTML] Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2
P Desai, CE Karl, B Ying, CY Liang, T Garcia-Salum… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Although vaccines have reduced COVID-19 disease burden, their efficacy in helminth
infection endemic areas is not well characterized. We evaluated the impact of infection by …
infection endemic areas is not well characterized. We evaluated the impact of infection by …
[HTML][HTML] Immunogenicity and efficacy of XBB. 1.5 rS vaccine against EG. 5.1 variant of SARS-CoV-2 in Syrian hamsters
J Boon, N Soudani, T Bricker, T Darling… - Research …, 2024 - ncbi.nlm.nih.gov
The continued emergence of SARS-CoV-2 variants necessitates updating COVID-19
vaccines to match circulating strains. The immunogenicity and efficacy of these vaccines …
vaccines to match circulating strains. The immunogenicity and efficacy of these vaccines …
Immunogenicity of an adenovirus-vectored bivalent vaccine against wild type SARS-CoV-2 and Omicron variants in a murine model
Y Ji, X Sui, W Miao, C Wang, Q Wang, Z Duan, B Wei… - Vaccine, 2024 - Elsevier
Background The emergence and rapid spread of new mutant strains of SARS-CoV-2
necessitate the development of a new generation vaccine capable of neutralizing a broad …
necessitate the development of a new generation vaccine capable of neutralizing a broad …