Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …

Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …

Rationale: Aging is one of the strongest risk factors for atherosclerosis. Yet whether aging
increases the risk of atherosclerosis independently of chronic hyperlipidemia is not known …

Introduction Diabetes, chronic kidney disease (CKD) and cardiovascular disease (CVD) are
cardiometabolic diseases that remain amongst the leading causes of morbidity and …

How exercise elicits systemic metabolic benefits in both muscles and non-contractile tissues
is unclear. Autophagy is a stress-induced lysosomal degradation pathway that mediates …

Prolonged hyperglycemia is toxic to pancreatic β cells, generating excessive reactive
oxygen species, defective glucose-stimulated insulin secretion, decreased insulin …

Exercise has multiple beneficial effects on health including decreasing the risk of
neurodegenerative diseases. Such effects are thought to be mediated (at least in part) by …

Inflammatory damage contributes to β cell failure in type 1 and 2 diabetes (T1D and T2D,
respectively). Mitochondria are damaged by inflammatory signaling in β cells, resulting in …

Macroautophagy/autophagy plays a vital role in the homeostasis of diverse cell types.
Vascular endothelial cells contribute to vascular health and play a unique role in vascular …

Methods Pancreases were collected from chloroquine-injected and non-injected non-obese
diabetes-resistant (NOR) and non-obese diabetic (NOD) mice. Age-and BMI-matched …