During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …

The treatment of HCV infection has evolved at an extremely rapid pace over the past few
years. The development of direct-acting antiviral agents, which potently inhibit different …

Zinc finger antiviral protein (ZAP) is a powerful restriction factor for viruses with elevated
CpG dinucleotide frequencies. We report that ZAP similarly mediates antiviral restriction …

Hepatitis C infection is the leading cause of liver diseases worldwide and a major health
concern that affects an estimated 3% of the global population. Novel therapies available …

The prevalence of intrinsically disordered protein regions, particularly in eukaryotic proteins,
and their clear functional advantages for signaling and gene regulation have created an …

Introduction: Direct-acting antivirals (DAA) have revolutionized the modern treatment of
chronic hepatitis C (HCV). These highly efficacious, well-tolerated, all-oral HCV regimens …

Replication and amplification of the viral genome is a key process for all viruses. For
hepatitis C virus (HCV), a positive-strand RNA virus, amplification of the viral genome …

Induction of membrane rearrangements in the cytoplasm of infected cells is a hallmark of
positive-strand RNA viruses. These altered membranes serve as scaffolds for the assembly …

Hepatitis C virus (HCV) infection is the main cause of chronic hepatitis, affecting an
estimated 150 million people worldwide. Initial exposure to HCV is most often followed by …

Flavonoids, stilbenes, and chalcones are plant secondary metabolites that often possess
diverse biological activities including anti-inflammatory, anti-cancer, and anti-viral activities …