Joint arthroplasty had revolutionized the outcome of orthopaedic surgery. Extensive and
collaborative work of many innovator surgeons had led to the development of durable …

Aseptic loosening and osteolysis are the most frequent late complications of total hip
arthroplasty (THA) leading to revision of the prosthesis. This review aims to demonstrate …

Pathological assessment of periprosthetic tissues is important, not only for diagnosis, but
also for understanding the pathobiology of implant failure. The host response to wear …

Increased failure rates due to metallic wear particle-associated adverse local tissue
reactions (ALTR) is a significant clinical problem in resurfacing and total hip arthroplasty …

The objective of Part I of this analysis was to identify the relevant physicochemical
characteristics of wear particles from cobalt-chromium alloy (CoCr) metal-on-metal (MoM) …

In hip arthroplasty the implants' articulating surfaces can be made of a cobalt-chromium-
molybdenum (CoCrMo) alloy. The use of these metal-on-metal (MoM) pairings can lead to …

Orthopedic implants heal well without complications in most patients but fail for unclear
reasons in some individuals. This study determined the relevance of metal hypersensitivity …

We performed a combined approach to identify suspected allergy to knee arthroplasty
(TKR): patch test (PT), lymphocyte transformation test (LTT), histopathology (overall grading; …

Aseptic loosening is the main reason for arthroplasty failure. The wear particles generated at
the tribological bearings are thought to induce an inflammatory tissue response, leading to …

Hypersensitivity reactions to implants in orthopaedic and trauma surgery are a rare but
devastating complication. They are considered as a delayed-type of hypersensitivity reaction …