Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …

Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …

Metabolic reprogramming of the tumor microenvironment (TME) and poor immunogenicity
are two of the challenges that cancer immunotherapies have to overcome for improved …

Amino acids are fundamental units of molecular components that are essential for sustaining
life; however, their metabolism is closely interconnected to the control systems of cell …

Epithelial ovarian cancer (EOC) is among the top five causes of cancer-related death in
women, largely reflecting early, prediagnosis dissemination of malignant cells to the …

Abstract Type I interferons (IFN-Is) are central regulators of anti-tumor immunity and
responses to immunotherapy, but they also drive the feedback inhibition underlying …

Tumor cells are dominant in the nutritional competition in the tumor microenvironment, and
their metabolic abnormalities often lead to microenvironmental acidosis and nutrient …

Metabolic alterations occur commonly in tumor cells as a way to adapt available energetic
sources for their proliferation, survival and resistance. Indoleamine 2, 3-dioxygenase 1 …

Indoleamine 2, 3-dioxygenase 1 (IDO1) is a potent immunosuppressive enzyme that inhibits
the antitumor immune response through both tryptophan metabolism and non-enzymatic …

Ovarian cancer is the most lethal gynecologic tumor, with the highest mortality rate.
Numerous studies have been conducted on the treatment of ovarian cancer in the hopes of …