Highlights•μ-OR biased agonists represent promising analgesics with improved therapeutic
profiles.•Protein-ligand interactions might account for biased ligands functional …

G-protein-coupled receptors (GPCRs) contribute to numerous physiological processes via
complex network mechanisms. While indirect signaling assays (Ca2+ mobilization, cAMP …

Multifunctional enhanced collagen materials in green biomanufacturing are highly desired
yet challenging due to the poor comprehensive performance caused by the adoption of …

The secretome is composed of cell surface membrane proteins and extracellular secreted
proteins that are synthesized via secretory machinery, accounting for approximately one …

G-protein-coupled receptors (GPCR) transmit extracellular signals into cells to regulate a
variety of cellular functions and are closely related to the homeostasis of the human body …

The retina-specific ABCA transporter, ABCA4, is essential for vision, and its genetic variants
are associated with a wide range of inherited retinal degenerative diseases, leading to …

Complex cellular targets such as G protein-coupled receptors (GPCRs), ion channels, and
other multi-transmembrane proteins represent a significant challenge for therapeutic …

Overexpression of biologically functional GPCRs and homogeneous purified protein
solutions are required to enable structural studies and protein-based biophysical assay …

Background: G protein-coupled receptors (GPCRs) represent the largest family of surface
proteins and are involved in the regulation of key physiological processes. GPCRs are …

In this research, I reported the details of biochemical approach platforms for protein structure
analysis and their significance in studies of G-protein coupled receptors (GPCRs) and …