RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

The 5′-terminal cap is a fundamental determinant of eukaryotic gene expression which
facilitates cap-dependent translation and protects mRNAs from exonucleolytic degradation …

Microtubules play crucial roles in cellular architecture, intracellular transport, and mitosis.
The availability of free tubulin subunits affects polymerization dynamics and microtubule …

PUMILIO (PUM) proteins belong to the highly conserved PUF family post-transcriptional
regulators involved in diverse biological processes. However, their function in …

The CCR4-NOT complex acts as a central player in the control of mRNA turnover and
mediates accelerated mRNA degradation upon HDAC inhibition. Here, we explored …

Translational control has emerged as a fundamental regulatory layer of proteome complexity
that governs cellular identity and functions. As initiation is the rate-limiting step of translation …

Posttranscriptional regulation of the maternal nanos mRNA is essential for the development
of the anterior–posterior axis of the Drosophila embryo. The nanos RNA is regulated by the …

Abstract Background The Ccr4-Not complex is mostly known as the major eukaryotic
deadenylase. However, several studies have uncovered roles of the complex, in particular of …

ABSTRACT PUF RNA-binding proteins are conserved stem cell regulators. Four PUF
proteins govern self-renewal of Caenorhabditis elegans germline stem cells together with …

Biological time keeping, or the duration and tempo at which biological processes occur, is a
phenomenon that drives dynamic molecular and morphological changes that manifest …