Automated chemical oligosaccharide synthesis: novel approach to traditional challenges

M Panza, SG Pistorio, KJ Stine… - Chemical reviews, 2018 - ACS Publications
Advances in carbohydrate chemistry have certainly made common oligosaccharides much
more accessible. However, many current methods still rely heavily upon specialized …

Oligosaccharide synthesis and translational innovation

L Krasnova, CH Wong - Journal of the American Chemical Society, 2019 - ACS Publications
The translation of biological glycosylation in humans to the clinical applications involves
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …

Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G

GBE Stewart-Jones, C Soto, T Lemmin, GY Chuang… - Cell, 2016 - cell.com
Summary The HIV-1-envelope (Env) trimer is covered by a glycan shield of∼ 90 N-linked
oligosaccharides, which comprises roughly half its mass and is a key component of HIV …

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers

E Falkowska, KM Le, A Ramos, KJ Doores, JH Lee… - Immunity, 2014 - cell.com
Broadly neutralizing HIV antibodies are much sought after (a) to guide vaccine design, both
as templates and as indicators of the authenticity of vaccine candidates,(b) to assist in …

A sugar‐based gelator for marine oil‐spill recovery

AM Vibhute, V Muvvala, KM Sureshan - Angewandte Chemie, 2016 - Wiley Online Library
Marine oil spills constitute an environmental disaster with severe adverse effects on the
economy and ecosystem. Phase‐selective organogelators (PSOGs), molecules that can …

Chemical and chemoenzymatic synthesis of glycoproteins for deciphering functions

LX Wang, MN Amin - Chemistry & biology, 2014 - cell.com
Glycoproteins are an important class of biomolecules involved in a number of biological
recognition processes. However, natural and recombinant glycoproteins are usually …

Efficient chemoenzymatic synthesis of an N-glycan isomer library

L Li, Y Liu, C Ma, J Qu, AD Calderon, B Wu, N Wei… - Chemical …, 2015 - pubs.rsc.org
Quantification, characterization and biofunctional studies of N-glycans on proteins remain
challenging tasks due to the complexity, diversity and low abundance of these glycans. The …

Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies

SS Shivatare, SH Chang, TI Tsai, SY Tseng… - Nature Chemistry, 2016 - nature.com
A new class of broadly neutralizing antibodies (bNAbs) from HIV donors has been reported
to target the glycans on gp120—a glycoprotein found on the surface of the virus envelope …

Recent advances on smart glycoconjugate vaccines in infections and cancer

M Anderluh, F Berti, A Bzducha‐Wróbel… - The FEBS …, 2022 - Wiley Online Library
Vaccination is one of the greatest achievements in biomedical research preventing death
and morbidity in many infectious diseases through the induction of pathogen‐specific …

Understanding the chemistry and biology of glycosylation with glycan synthesis

L Krasnova, CH Wong - Annual review of biochemistry, 2016 - annualreviews.org
Glycoscience research has been significantly impeded by the complex compositions of the
glycans present in biological molecules and the lack of convenient tools suitable for studying …