The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …

Histone modifications are key factors in chromatin packaging, and are responsible for gene
regulation during cell fate determination and development. Abnormal alterations in histone …

Abstract Skp1-Cul1-F-box protein (SCF) ubiquitin E3 ligases play important roles in cancer
development and serve as a promising therapeutic target in cancer therapy. Brusatol (Bru), a …

Signaling by the Rho GTPase Rac1 is key to the regulation of cytoskeletal dynamics, cell
spreading and adhesion. It is widely accepted that the inactive form of Rac1 is bound by Rho …

MLN4924 is a potent and selective small-molecule inhibitor of NEDD8-activating enzyme,
which showed antitumor effect in several types of malignant tumor types. However, the …

Protein neddylation is a post-translational modification, and its best recognized substrates
are cullin family proteins, which are the core component of Cullin-RING ligases (CRLs) …

The cullin-RING E3 ligases (CRLs) are the biggest components of the E3 ubiquitin ligase
protein family, and they represent an essential role in various diseases that occur because …

Epigenetic alterations have been functionally linked to ovarian cancer development and
occurrence. The CXXC zinc finger protein 1 (CFP1) is an epigenetic regulator involved in …

The identification of new therapeutic targets and the development of innovative therapeutic
approaches are the most important challenges for osteosarcoma treatment. In fact, despite …

Colon cancer (CC) is the third most diagnosed cancers globally and second most lethal
malignancy in both men and women due to aggressive metastatic ability. Genetic or somatic …