Oxidative stress and cellular response to doxorubicin: a common factor in the complex milieu of anthracycline cardiotoxicity

D Cappetta, A De Angelis, L Sapio… - Oxidative medicine …, 2017 - Wiley Online Library
The production of reactive species is a core of the redox cycling profile of anthracyclines.
However, these molecular characteristics can be viewed as a double‐edged sword acting …

Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing

GK Kolluru, SC Bir, CG Kevil - International journal of vascular …, 2012 - Wiley Online Library
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate
hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted …

Dysfunctional and proinflammatory regulatory T-lymphocytes are essential for adverse cardiac remodeling in ischemic cardiomyopathy

SS Bansal, MA Ismahil, M Goel, G Zhou, G Rokosh… - Circulation, 2019 - Am Heart Assoc
Background: Heart failure (HF) is a state of inappropriately sustained inflammation,
suggesting the loss of normal immunosuppressive mechanisms. Regulatory T-lymphocytes …

New insight into dyslipidemia‐induced cellular senescence in atherosclerosis

Q Xiang, F Tian, J Xu, X Du, S Zhang… - Biological Reviews, 2022 - Wiley Online Library
Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …

Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use

GP Fadini, D Losordo, S Dimmeler - Circulation research, 2012 - Am Heart Assoc
Diverse subsets of endothelial progenitor cells (EPCs) are used for the treatment of ischemic
diseases in clinical trials, and circulating EPCs levels are considered as biomarkers for …

Vascular toxic effects of cancer therapies

J Herrmann - Nature Reviews Cardiology, 2020 - nature.com
Cancer therapies can lead to a broad spectrum of cardiovascular complications. Among
these, cardiotoxicities remain of prime concern, but vascular toxicities have emerged as the …

Human endothelial progenitor cells

MC Yoder - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
Human endothelial progenitor cells (EPCs) have been generally defined as circulating cells
that express a variety of cell surface markers similar to those expressed by vascular …

Vascular actions of estrogens: functional implications

VM Miller, SP Duckles - Pharmacological reviews, 2008 - ASPET
The impact of estrogen exposure in preventing or treating cardiovascular disease is
controversial. But it is clear that estrogen has important effects on vascular physiology and …

Methods for evaluating endothelial function: a position statement from the European Society of Cardiology Working Group on Peripheral Circulation

J Lekakis, P Abraham, A Balbarini… - European Journal …, 2011 - journals.sagepub.com
The endothelium holds a pivotal role in cardiovascular health and disease. Assessment of
its function was until recently limited to experimental designs due to its location. The advent …

Endothelial progenitor cells: identity defined?

F Timmermans, J Plum, MC Yöder… - Journal of cellular …, 2009 - Wiley Online Library
• Introduction• The proof‐of‐concept in vivo: the cell, the read‐out and the animal model‐The
CEPC: Still a putative cell‐Do CEPCs play an essential role in vascular (patho) physiology …