The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Bacterial lipoproteins are synthesized as precursors in the cytoplasm and processed into
mature forms on the cytoplasmic membrane. A lipid moiety attached to the N terminus …

Innate immune receptors respond to common structural patterns in microbial molecules and
are called pattern recognition receptors. Toll-like receptors (TLRs) play critical roles in the …

Bacterial lipoproteins are peripherally anchored membrane proteins that play a variety of
roles in bacterial physiology and virulence in monoderm (single membrane-enveloped, eg …

Mycobacterium tuberculosis (Mtb) can withstand months of antibiotic treatment. An important
goal of tuberculosis research is to shorten the treatment to reduce the burden on patients …

Tuberculosis (TB) remains the second most common cause of death due to a single
infectious agent. The cell envelope of Mycobacterium tuberculosis (Mtb), the causative agent …

RA is a debilitating disorder that manifests as chronic localized synovial and systemic
inflammation leading to progressive joint destruction. Recent advances in the molecular …

Abstract The hygiene or “Old Friends” hypothesis proposes that the epidemic of
inflammatory disease in modern urban societies stems at least in part from reduced …

Mycobacterium tuberculosis is an intracellular pathogen that infects lung macrophages and
releases microbial factors that regulate host defense. M. tuberculosis lipoproteins and …

Abstract Mannose-capped lipoarabinomannan (ManLAM), present in all members of the
Mycobacterium tuberculosis complex and in other pathogenic Mycobacterium spp, is a high …