Understanding human embryology has historically relied on comparative approaches using
mammalian model organisms. With the advent of low-input methods to investigate genetic …

The preimplantation mouse embryo is a simple self-contained system, making it an excellent
model to discover how mammalian cells function in real time and in vivo. Work over the last …

The arrangement (syntax) of transcription factor (TF) binding motifs is an important part of the
cis-regulatory code, yet remains elusive. We introduce a deep learning model, BPNet, that …

The epiblast is the source of all mammalian embryonic tissues and of pluripotent embryonic
stem cells. It differentiates alongside the primitive endoderm in a “salt and pepper” pattern …

Variable levels of DNA methylation have been reported at tissue-specific differential
methylation regions (DMRs) overlapping enhancers, including super-enhancers (SEs) …

The pioneer activity of transcription factors allows for opening of inaccessible regulatory
elements and has been extensively studied in the context of cellular differentiation and …

During preimplantation development, the embryo undergoes two consecutive lineages
specifications. The first cell fate decision determines which cells give rise to the …

SOX 2 and OCT 4 are pioneer transcription factors playing a key role in embryonic stem (ES)
cell self‐renewal and differentiation. How temporal fluctuations in their expression levels …

The blastocyst is a conserved stage and distinct milestone in the development of the
mammalian embryo. Blastocyst stage embryos comprise three cell lineages which arise …

Simple Summary The fusion between sperm and oocyte results in a zygote, which is a single
totipotent cell with the ability to develop into a functional organism. Totipotent cells can give …