Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis
MA Rocca, MP Amato, N De Stefano… - The Lancet …, 2015 - thelancet.com
In patients with multiple sclerosis (MS), grey matter damage is widespread and might
underlie many of the clinical symptoms, especially cognitive impairment. This relation …
underlie many of the clinical symptoms, especially cognitive impairment. This relation …
Clinically isolated syndromes
DH Miller, DT Chard, O Ciccarelli - The Lancet Neurology, 2012 - thelancet.com
Clinically isolated syndrome (CIS) is a term that describes a first clinical episode with
features suggestive of multiple sclerosis (MS). It usually occurs in young adults and affects …
features suggestive of multiple sclerosis (MS). It usually occurs in young adults and affects …
Correlated gene expression supports synchronous activity in brain networks
During rest, brain activity is synchronized between different regions widely distributed
throughout the brain, forming functional networks. However, the molecular mechanisms …
throughout the brain, forming functional networks. However, the molecular mechanisms …
Intrinsic coupling modes: multiscale interactions in ongoing brain activity
Intrinsic coupling constitutes a key feature of ongoing brain activity, which exhibits rich
spatiotemporal patterning and contains information that influences cognitive processing. We …
spatiotemporal patterning and contains information that influences cognitive processing. We …
Injured brains and adaptive networks: the benefits and costs of hyperconnectivity
FG Hillary, JH Grafman - Trends in cognitive sciences, 2017 - cell.com
A common finding in human functional brain-imaging studies is that damage to neural
systems paradoxically results in enhanced functional connectivity between network regions …
systems paradoxically results in enhanced functional connectivity between network regions …
Resting-state functional MR imaging: a new window to the brain
Resting-state (RS) functional magnetic resonance (MR) imaging constitutes a novel
paradigm that examines spontaneous brain function by using blood oxygen level …
paradigm that examines spontaneous brain function by using blood oxygen level …
Principal components of functional connectivity: a new approach to study dynamic brain connectivity during rest
Functional connectivity (FC) as measured by correlation between fMRI BOLD time courses
of distinct brain regions has revealed meaningful organization of spontaneous fluctuations in …
of distinct brain regions has revealed meaningful organization of spontaneous fluctuations in …
Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment
MAA Binnewijzend, MM Schoonheim… - Neurobiology of …, 2012 - Elsevier
Regional functional connectivity (FC) of 39 patients with Alzheimer's disease (AD), 23
patients with mild cognitive impairment (MCI), and 43 healthy elderly controls was studied …
patients with mild cognitive impairment (MCI), and 43 healthy elderly controls was studied …
Mind the gap: from neurons to networks to outcomes in multiple sclerosis
DT Chard, AAS Alahmadi, B Audoin… - Nature Reviews …, 2021 - nature.com
MRI studies have provided valuable insights into the structure and function of neural
networks, particularly in health and in classical neurodegenerative conditions such as …
networks, particularly in health and in classical neurodegenerative conditions such as …
Network collapse and cognitive impairment in multiple sclerosis
The current field of multiple sclerosis (MS) research is an active and highly interesting one:
structural abnormalities such as inflammatory lesions and brain atrophy are studied with a …
structural abnormalities such as inflammatory lesions and brain atrophy are studied with a …