Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis

MA Rocca, MP Amato, N De Stefano… - The Lancet …, 2015 - thelancet.com
In patients with multiple sclerosis (MS), grey matter damage is widespread and might
underlie many of the clinical symptoms, especially cognitive impairment. This relation …

Clinically isolated syndromes

DH Miller, DT Chard, O Ciccarelli - The Lancet Neurology, 2012 - thelancet.com
Clinically isolated syndrome (CIS) is a term that describes a first clinical episode with
features suggestive of multiple sclerosis (MS). It usually occurs in young adults and affects …

Correlated gene expression supports synchronous activity in brain networks

J Richiardi, A Altmann, AC Milazzo, C Chang… - Science, 2015 - science.org
During rest, brain activity is synchronized between different regions widely distributed
throughout the brain, forming functional networks. However, the molecular mechanisms …

Intrinsic coupling modes: multiscale interactions in ongoing brain activity

AK Engel, C Gerloff, CC Hilgetag, G Nolte - Neuron, 2013 - cell.com
Intrinsic coupling constitutes a key feature of ongoing brain activity, which exhibits rich
spatiotemporal patterning and contains information that influences cognitive processing. We …

Injured brains and adaptive networks: the benefits and costs of hyperconnectivity

FG Hillary, JH Grafman - Trends in cognitive sciences, 2017 - cell.com
A common finding in human functional brain-imaging studies is that damage to neural
systems paradoxically results in enhanced functional connectivity between network regions …

Resting-state functional MR imaging: a new window to the brain

F Barkhof, S Haller, SARB Rombouts - Radiology, 2014 - pubs.rsna.org
Resting-state (RS) functional magnetic resonance (MR) imaging constitutes a novel
paradigm that examines spontaneous brain function by using blood oxygen level …

Principal components of functional connectivity: a new approach to study dynamic brain connectivity during rest

N Leonardi, J Richiardi, M Gschwind, S Simioni… - NeuroImage, 2013 - Elsevier
Functional connectivity (FC) as measured by correlation between fMRI BOLD time courses
of distinct brain regions has revealed meaningful organization of spontaneous fluctuations in …

Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment

MAA Binnewijzend, MM Schoonheim… - Neurobiology of …, 2012 - Elsevier
Regional functional connectivity (FC) of 39 patients with Alzheimer's disease (AD), 23
patients with mild cognitive impairment (MCI), and 43 healthy elderly controls was studied …

Mind the gap: from neurons to networks to outcomes in multiple sclerosis

DT Chard, AAS Alahmadi, B Audoin… - Nature Reviews …, 2021 - nature.com
MRI studies have provided valuable insights into the structure and function of neural
networks, particularly in health and in classical neurodegenerative conditions such as …

Network collapse and cognitive impairment in multiple sclerosis

MM Schoonheim, KA Meijer, JJG Geurts - Frontiers in neurology, 2015 - frontiersin.org
The current field of multiple sclerosis (MS) research is an active and highly interesting one:
structural abnormalities such as inflammatory lesions and brain atrophy are studied with a …