The transforming growth factor-beta (TGF-β) signaling pathway is a vital regulator of cell
proliferation, differentiation, apoptosis, and extracellular matrix production. It functions …

Chagas' disease and Lyme disease are two endemic, vector-borne zoonotic infectious
diseases that impact multiple organ systems, including the heart. Chagas' cardiomyopathy is …

Background Chronic Chagas Cardiomyopathy (CCM) is characterized by a unique
pathophysiology in which inflammatory, microvascular and neuroendocrine processes …

Trypanosoma cruzi, the etiological agent of Chagas Disease, causes severe morbidity,
mortality, and economic burden worldwide. Though originally endemic to Central and South …

Underactive bladder and impaired bladder compliance are irreversible problems associated
with bladder fibrosis. Remodeling of the extracellular matrix is regarded as an important …

Chagas disease (CD), caused by Trypanosoma cruzi, is a degenerative heart condition. In
the present study, we investigated the role of poly [ADP-ribose] polymerase 1/activator …

Background Pulmonary fibrosis (PF) is an irreversible and fatal lung disease with limited
therapeutic options. G protein-coupled receptor 40 (GPR40) has been developed as a …

Trypanosoma cruzi causes Chagas disease, a neglected disease that can be divided,
overall, into acute and chronic phases. Understanding the mechanisms underlying its …

Chagas cardiomyopathy is caused by Trypanosoma cruzi (Tc). We identified two candidate
antigens (TcG2 and TcG4) that elicit antibodies and T cell responses in naturally infected …

Trypanosoma cruzi, the protozoan parasite causative agent of Chagas disease, affects
about seven million people worldwide, representing a major global public health concern …