Several mechanisms and cell types are involved in the regulation of the immune response.
These include mostly regulatory T cells (Tregs), regulatory macrophages (Mregs), myeloid …

Simple Summary Tumor-Associated Macrophages (TAMs) play an important role in the
development of tumors, modulation of neoangiogenesis, immune suppression, and …

Macrophages are key cellular components of the innate immunity, acting as the main player
in the first‐line defence against the pathogens and modulating homeostatic and …

The critical role of angiogenesis in promoting tumor growth and metastasis is strongly
established. However, tumors show considerable variation in angiogenic characteristics and …

During the past decades, anticancer immunotherapy has evolved from a promising
therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now …

Breast cancer is the most commonly occurring cancer in women of Western countries and is
the leading cause of cancer-related mortality. The breast tumor microenvironment contains …

Stromal immune cells constitute the tumor microenvironment. These immune cell subsets
include myeloid cells, the so-called tumor-associated myeloid cells (TAMCs), which are of …

The majority of basic and clinical studies have shown a protumor function of tumor‐
associated macrophages (TAMs), which represent a large proportion of matrix cells. TAMs …

Around 15 years ago, imatinib mesylate (Gleevec® or Glivec®, Novartis, Switzerland)
became the very first'targeted'anticancer drug to be clinically approved. This drug constitutes …

Tumor-associated macrophages (TAMs) form approximately 50% of tumor mass. TAMs were
shown to promote tumor growth by suppressing immunocompetent cells, inducing …