Coagulation pathways in neurological diseases: multiple sclerosis
Significant progress has been made in understanding the complex interactions between the
coagulation system and inflammation and autoimmunity. Increased blood-brain-barrier …
coagulation system and inflammation and autoimmunity. Increased blood-brain-barrier …
[HTML][HTML] Homeostatic effects of coagulation protease‐dependent signaling and protease activated receptors
B Isermann - Journal of Thrombosis and Haemostasis, 2017 - Elsevier
A homeostatic function of the coagulation system in regard to hemostasis is well established.
Homeostasis of blood coagulation depends partially on protease activated receptor (PAR) …
Homeostasis of blood coagulation depends partially on protease activated receptor (PAR) …
Microglial homeostasis requires balanced CSF-1/CSF-2 receptor signaling
CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids
and pigmented glia (ALSP). Previous studies in the Csf1r+/− mouse model of ALSP …
and pigmented glia (ALSP). Previous studies in the Csf1r+/− mouse model of ALSP …
Thrombomodulin facilitates peripheral nerve regeneration through regulating M1/M2 switching
TC Huang, HL Wu, SH Chen, YT Wang… - Journal of …, 2020 - Springer
Background Excessive inflammation within damaged tissue usually leads to delayed or
insufficient regeneration, and nerves in the peripheral nervous system (PNS) generally do …
insufficient regeneration, and nerves in the peripheral nervous system (PNS) generally do …
Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing
Cellular senescence is a stress-induced, stable cell cycle arrest phenotype which generates
a pro-inflammatory microenvironment, leading to chronic inflammation and age-associated …
a pro-inflammatory microenvironment, leading to chronic inflammation and age-associated …
A perspective of coagulation dysfunction in multiple sclerosis and in experimental allergic encephalomyelitis
D Plantone, M Inglese, M Salvetti… - Frontiers in …, 2019 - frontiersin.org
A key role of both coagulation and vascular thrombosis has been reported since the first
descriptions of multiple sclerosis (MS). Subsequently, the observation of a close …
descriptions of multiple sclerosis (MS). Subsequently, the observation of a close …
Blood protein profiles related to preterm birth and retinopathy of prematurity
Background Nearly one in ten children is born preterm. The degree of immaturity is a
determinant of the infant's health. Extremely preterm infants have higher morbidity and …
determinant of the infant's health. Extremely preterm infants have higher morbidity and …
Activated protein C ameliorates tubular mitochondrial reactive oxygen species and inflammation in diabetic kidney disease
R Rana, J Manoharan, A Gupta, D Gupta, A Elwakiel… - Nutrients, 2022 - mdpi.com
Diabetic kidney disease (DKD) is an emerging pandemic, paralleling the worldwide
increase in obesity and diabetes mellitus. DKD is now the most frequent cause of end-stage …
increase in obesity and diabetes mellitus. DKD is now the most frequent cause of end-stage …
Hemostasis biomarkers in multiple sclerosis
Background and purpose The aim was to investigate the plasma levels of hemostasis
components in multiple sclerosis (MS) and their association with clinical and magnetic …
components in multiple sclerosis (MS) and their association with clinical and magnetic …
Activated protein C attenuates experimental autoimmune encephalomyelitis progression by enhancing vascular integrity and suppressing microglial activation
Background Activated protein C (APC), a serine protease with antithrombotic effects,
protects in animal models of ischemic stroke by suppressing inflammation and enhancing …
protects in animal models of ischemic stroke by suppressing inflammation and enhancing …