Prospects and challenges of CRISPR/Cas genome editing for the study and control of neglected vector‐borne nematode diseases

M Zamanian, EC Andersen - The FEBS journal, 2016 - Wiley Online Library
Neglected tropical diseases caused by parasitic nematodes inflict an immense health and
socioeconomic burden throughout much of the developing world. Current estimates indicate …

FLP-18 functions through the G-protein-coupled receptors NPR-1 and NPR-4 to modulate reversal length in Caenorhabditis elegans

A Bhardwaj, S Thapliyal, Y Dahiya… - Journal of …, 2018 - Soc Neuroscience
Animal behavior is critically dependent on the activity of neuropeptides. Reversals, one of
the most conspicuous behaviors in Caenorhabditis elegans, plays an important role in …

Ascaris suum Informs Extrasynaptic Volume Transmission in Nematodes

LE Atkinson, Y Liu, F McKay, E Vandewyer… - ACS chemical …, 2021 - ACS Publications
Neural circuit synaptic connectivities (the connectome) provide the anatomical foundation for
our understanding of nematode nervous system function. However, other nonsynaptic routes …

[HTML][HTML] In silico analyses of neuropeptide-like protein (NLP) profiles in parasitic nematodes

FM McKay, CJ McCoy, B Crooks, NJ Marks… - International Journal for …, 2022 - Elsevier
Nematode parasite infections cause disease in humans and animals and threaten global
food security by reducing productivity in livestock and crop farming. The escalation of …

Tool-driven advances in neuropeptide research from a nematode parasite perspective

CJ McCoy, LE Atkinson, E Robb, NJ Marks… - Trends in …, 2017 - cell.com
Expanding 'omics' datasets for parasitic nematodes have accelerated the identification of
putative drug targets derived from the nematode nervous system. However, novel drug …

A Chemosensory GPCR as a Potential Target to Control the Root-Knot Nematode Meloidogyne incognita Parasitism in Plants

E Bresso, D Fernandez, DX Amora, P Noel, AS Petitot… - Molecules, 2019 - mdpi.com
Root-knot nematodes (RKN), from the Meloidogyne genus, have a worldwide distribution
and cause severe economic damage to many life-sustaining crops. Because of their lack of …

Exploitation of phylum-spanning omics resources reveals complexity in the nematode FLP signalling system and provides insights into flp-gene evolution

CJ McCoy, C Wray, L Freeman, BA Crooks, L Golinelli… - bioRxiv, 2024 - biorxiv.org
Background: Parasitic nematodes significantly undermine global human and animal health
and productivity. Parasite control is reliant on anthelmintic administration however over-use …

Extrasynaptic volume transmission: A novel route for neuropeptide signaling in nematodes

LE Atkinson, Y Liu, F McKay, E Vandewyer, C Viau… - bioRxiv, 2020 - biorxiv.org
Neural circuit synaptic connectivities (the connectome) provide the anatomical foundation for
our understanding of nematode nervous system function. However, other non-synaptic …

[图书][B] Characterisation of neuropeptide GPCRs NPR-4 and NPR-5 from the parasite Brugia malayi

Y Hui - 2019 - search.proquest.com
Parasitic infections of humans and animals are often associated with high morbidity and
socioeconomic burden. Highly prevalent in developing countries, they contribute to the …

Study of reversal behavior in Caenorhabditis elegans

A Bhardwaj - 2019 - 210.212.36.82
Animals have different foraging strategies to find new sources of food. In Caenorhabditis
elegans, these strategies are governed by changing the frequency and duration of the basic …