Embryos express paternal antigens that are foreign to the mother, but the mother provides a
special immune milieu at the fetal–maternal interface to permit rather than reject the embryo …

T-cell trafficking at vascular sites has emerged as a key step in antitumour immunity.
Chemokines are credited with guiding the multistep recruitment of CD8+ T cells across …

Infiltration of regulatory T (Treg) cells, an immunosuppressive population of CD4+ T cells,
into solid cancers represents a barrier to cancer immunotherapy. Chemokine receptors are …

Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating
inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors …

Respiratory virus infections, such as those mediated by influenza virus, parainfluenza virus,
respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus (SARS …

The impact of complement on cancer metastasis has not been well studied. In this report, we
demonstrate in a preclinical mouse model of breast cancer that the complement …

Obesity in the United States and worldwide reached epidemic proportions within the last 20
years. Obesity is a very powerful health determinant or indicator that facilitates the …

The purpose of this study was to investigate the effects of chronically inhaled particulate
matter< 2.5 μm (PM2. 5) on inflammatory cell populations in the lung and systemic …

Aberrant activation of interferon (IFN)-γ signaling plays a key role in several autoimmune
skin diseases, including lupus erythematosus, alopecia areata, vitiligo, and lichen planus …

It has been over 30 yrs since the modern era of lung transplantation commenced and what
was then the “new frontier and exceptional” has now become “routine and expected”. Strong …