The central nervous system (CNS) receives information from afferent neurons, circulating
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …

Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of
the body's energy status, since they act in an opposite manner to modulate appetite and …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Abstract Pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the
hypothalamus represent key regulators of metabolic homeostasis. Electrophysiological and …

Neuronal activation is fundamental to information processing by the brain and requires
mitochondrial energy metabolism. Mitochondrial Ca2+ uptake by the mitochondrial Ca2+ …

Appropriate cristae remodeling is a determinant of mitochondrial function and bioenergetics
and thus represents a crucial process for cellular metabolic adaptations. Here, we show that …

Calorie-rich diets induce hyperphagia and promote obesity, although the underlying
mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of …

Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal
pathways in control of energy and glucose homeostasis. However, the specific ceramide …

Obesity is associated with hypogonadism in males, characterized by low testosterone and
sperm number. Previous studies determined that these stem from dysregulation of …

Chronic stress exposure induces maladaptive behavioral responses and increases
susceptibility to neuropsychiatric conditions. However, specific neuronal populations and …