Nowadays, pharmaceutical industry demands competitive and eco-friendly processes for
active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole …

Deaminases, ubiquitous enzymes found in all living organisms from bacteria to humans,
serve diverse and crucial functions. Notably, purine and pyrimidine deaminases, while …

Enzyme-based processes promise a sustainable and environmentally-friendly solution to
the pollution that results from industrial technologies. Thermozymes are extremely …

Molnupiravir (Lagevrio®) is an orally‐administered anti‐COVID‐19 agent. Due to the
urgency to meet the worldwide demand and the growing environmental concern, there is a …

The present work describes the functional and structural characterization of adenine
phosphoribosyltransferase 2 from Thermus thermophilus HB8 (TtAPRT2). The combination …

Enzyme-mediated processes have proven to be a valuable and sustainable alternative to
traditional chemical methods. In this regard, the use of multi-enzymatic systems enables the …

Due to their similarity to natural counterparts, nucleic acid derivatives (nucleobases,
nucleosides, and nucleotides, among others) are interesting molecules for pharmaceutical …

Biocatalysis reproduce nature's synthetic strategies in order to synthesize different organic
compounds. Natural metabolic pathways usually involve complex networks to support …

Background: In recent years, enzymatic methods have shown to be an efficient and
sustainable alternative for the synthesis of nucleosides and nucleoside-5'-monophosphates …

In our search for novel biocatalysts for the synthesis of nucleic acid derivatives, we found a
good candidate in a putative dual-domain hypoxanthine-guanine phosphoribosyltransferase …