Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Cell migration and invasion play an important role in the development of cancer. Cell
migration is associated with several specific actin filament–based structures, including …

Our previous studies demonstrated that the natural compound emodin blocks the tumor-
promoting feedforward interactions between cancer cells and macrophages, and thus …

During the metastatic progression, invading cells might achieve degradation and
subsequent invasion into the extracellular matrix (ECM) and the underlying vasculature …

Background Metastasis is the leading cause of cancer mortality and is a major hurdle for
lung cancer treatment. Invadopodia, which are cancer-specific protrusive structures, play a …

Metastatic cancer cells dynamically adjust their shape to adhere, invade, migrate, and
expand to generate secondary tumors. Inherent to these processes is the constant assembly …

Despite the undisputable role of the small GTPase Rac1 in the regulation of actin
cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) …

Invadopodia are cell protrusions that mediate cancer cell extravasation but the
microenvironmental cues and signaling factors that induce invadopodia formation during …

Background: Triple-negative breast cancer (TNBC) is an aggressive malignancy with high
heterogeneity. However, the alternative polyadenylation (APA) profiles of TNBC remain …

Cell invasion is a highly complex process that requires the coordination of cell migration and
degradation of the extracellular matrix. In melanoma cells, as in many highly invasive cancer …