Mechanisms and roles of podosomes and invadopodia
S Linder, P Cervero, R Eddy, J Condeelis - Nature Reviews Molecular …, 2023 - nature.com
Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …
endothelial barriers occurs in both physiological and pathological scenarios such as …
Rho GTPases and related signaling complexes in cell migration and invasion
X Guan, X Guan, C Dong, Z Jiao - Experimental cell research, 2020 - Elsevier
Cell migration and invasion play an important role in the development of cancer. Cell
migration is associated with several specific actin filament–based structures, including …
migration is associated with several specific actin filament–based structures, including …
[HTML][HTML] Emodin reduces breast cancer lung metastasis by suppressing macrophage-induced breast cancer cell epithelial-mesenchymal transition and cancer stem …
Our previous studies demonstrated that the natural compound emodin blocks the tumor-
promoting feedforward interactions between cancer cells and macrophages, and thus …
promoting feedforward interactions between cancer cells and macrophages, and thus …
[HTML][HTML] Tumor cellular and microenvironmental cues controlling invadopodia formation
During the metastatic progression, invading cells might achieve degradation and
subsequent invasion into the extracellular matrix (ECM) and the underlying vasculature …
subsequent invasion into the extracellular matrix (ECM) and the underlying vasculature …
[HTML][HTML] miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene
Y Li, H Zhang, H Gong, Y Yuan, Y Li, C Wang… - Journal of Experimental …, 2018 - Springer
Background Metastasis is the leading cause of cancer mortality and is a major hurdle for
lung cancer treatment. Invadopodia, which are cancer-specific protrusive structures, play a …
lung cancer treatment. Invadopodia, which are cancer-specific protrusive structures, play a …
Guanine nucleotide exchange factors for Rho GTPases (RhoGEFs) as oncogenic effectors and strategic therapeutic targets in metastatic cancer
RD Cervantes-Villagrana, I García-Jiménez… - Cellular …, 2023 - Elsevier
Metastatic cancer cells dynamically adjust their shape to adhere, invade, migrate, and
expand to generate secondary tumors. Inherent to these processes is the constant assembly …
expand to generate secondary tumors. Inherent to these processes is the constant assembly …
[HTML][HTML] FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
Despite the undisputable role of the small GTPase Rac1 in the regulation of actin
cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) …
cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) …
[HTML][HTML] Invadopodia are chemosensing protrusions that guide cancer cell extravasation to promote brain tropism in metastasis
KC Williams, MA Cepeda, S Javed, K Searle… - Oncogene, 2019 - nature.com
Invadopodia are cell protrusions that mediate cancer cell extravasation but the
microenvironmental cues and signaling factors that induce invadopodia formation during …
microenvironmental cues and signaling factors that induce invadopodia formation during …
[HTML][HTML] Dissecting the heterogeneity of the alternative polyadenylation profiles in triple-negative breast cancers
L Wang, GT Lang, MZ Xue, L Yang, L Chen, L Yao… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Triple-negative breast cancer (TNBC) is an aggressive malignancy with high
heterogeneity. However, the alternative polyadenylation (APA) profiles of TNBC remain …
heterogeneity. However, the alternative polyadenylation (APA) profiles of TNBC remain …
[HTML][HTML] Protein dynamics at invadopodia control invasion–migration transitions in melanoma cells
M Legrand, A Mousson, P Carl, L Rossé… - Cell Death & …, 2023 - nature.com
Cell invasion is a highly complex process that requires the coordination of cell migration and
degradation of the extracellular matrix. In melanoma cells, as in many highly invasive cancer …
degradation of the extracellular matrix. In melanoma cells, as in many highly invasive cancer …