The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond
N Stopa, JE Krebs, D Shechter - Cellular and molecular life sciences, 2015 - Springer
Post-translational arginine methylation is responsible for regulation of many biological
processes. The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1 …
processes. The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1 …
[HTML][HTML] Chemical biology of protein arginine modifications in epigenetic regulation
J Fuhrmann, KW Clancy, PR Thompson - Chemical reviews, 2015 - ACS Publications
Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
Medicinal chemistry strategies targeting PRMT5 for cancer therapy
S Fu, Q Zheng, D Zhang, C Lin, L Ouyang… - European Journal of …, 2022 - Elsevier
Abstract Protein arginine methyltransferases 5 (PRMT5), a therapeutic target whose main
physiological function is mono-and symmetric dimethylation of arginine, has drawn …
physiological function is mono-and symmetric dimethylation of arginine, has drawn …
[HTML][HTML] Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer
Protein arginine methyltransferases (PRMTs) are known for their ability to catalyze
methylation of specific arginine residues in a wide variety of cellular proteins, which are …
methylation of specific arginine residues in a wide variety of cellular proteins, which are …
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response
D Ma, M Yang, Q Wang, C Sun, H Shi, W Jing, Y Bi… - Science …, 2021 - science.org
Cyclic GMP-AMP synthase (cGAS) functions as an essential DNA sensor, which senses the
cytoplasmic double-stranded DNA and activates the antiviral response. However, the …
cytoplasmic double-stranded DNA and activates the antiviral response. However, the …
Prmt5 is a regulator of muscle stem cell expansion in adult mice
T Zhang, S Günther, M Looso, C Künne… - Nature …, 2015 - nature.com
Skeletal muscle stem cells (MuSC), also called satellite cells, are indispensable for
maintenance and regeneration of adult skeletal muscles. Yet, a comprehensive picture of …
maintenance and regeneration of adult skeletal muscles. Yet, a comprehensive picture of …
[HTML][HTML] PRMT5 in gene regulation and hematologic malignancies
Arginine methylation is a common posttranslational modification that governs important
cellular processes and impacts development, cell growth, proliferation, and differentiation …
cellular processes and impacts development, cell growth, proliferation, and differentiation …
[HTML][HTML] Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects
RNA-binding proteins play important roles in X-linked intellectual disability (XLID). In this
study, we investigate the contribution of the XLID-associated RBMX in neuronal …
study, we investigate the contribution of the XLID-associated RBMX in neuronal …
The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer
M Rengasamy, F Zhang, A Vashisht… - Nucleic acids …, 2017 - academic.oup.com
We observed overexpression and increased intra-nuclear accumulation of the
PRMT5/WDR77 in breast cancer cell lines relative to immortalized breast epithelial cells …
PRMT5/WDR77 in breast cancer cell lines relative to immortalized breast epithelial cells …