Many see the periaqueductal gray (PAG) as a region responsible for the downstream control
of defensive reactions. Here we provide a detailed review of anatomical and functional data …

In this review study, we aimed to introduce the orexinergic system as an important signaling
pathway involved in a variety of cognitive functions such as memory, motivation, and reward …

Relaxin‐3 has been proposed to modulate emotional–behavioural functions such as
arousal and behavioural activation, appetite regulation, stress responses, anxiety, memory …

Key points Relaxin‐3 is a stress‐responsive neuropeptide that acts at its cognate receptor,
RXFP3, to alter behaviours including feeding. In this study, we have demonstrated a direct …

Orexins are hypothalamic neuropeptides originally discovered to play a role in the
regulation of feeding behaviour. The broad connections of orexin neurons to …

Binge-eating disorder is the most common eating disorder. Various neuropeptides play
important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which …

Many physiological processes fluctuate throughout the day/night and daily fluctuations are
observed in brain and peripheral levels of several hormones, neuropeptides and …

Abstract The neuropeptide relaxin-3 (RLN3) binds with high affinity to its cognate receptor,
relaxin-family peptide receptor 3 (RXFP3), and with lower affinity to RXFP1, the cognate …

Relaxin‐3 (RLN3) is a neuropeptide that is strongly expressed in the pontine nucleus
incertus (NI) and binds with high affinity to its cognate receptor RXFP3. Central …

Abstract The relaxin-3/RXFP3 system is one of several neuropeptidergic systems putatively
implicated in regulating the behavioural alterations that characterise clinical depression and …