Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

In many solid tumor types, tumor-associated macrophages (TAMs) are important
components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly …

Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only
by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between …

Spatial transcriptomics allows for the measurement of RNA abundance at a high spatial
resolution, making it possible to systematically link the morphology of cellular …

Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …

Macrophages are critical regulators of tissue homeostasis but are also abundant in the
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …

Tumor-associated macrophages (TAMs) are important tumor-promoting cells in the breast
tumor microenvironment. Preclinically TAMs stimulate breast tumor progression, including …

Macrophages are key cellular components of the innate immunity, acting as the main player
in the first-line defence against the pathogens and modulating homeostatic and …

Tumorigenesis is not only determined by the intrinsic properties of cancer cells but also by
their interactions with components of the tumor microenvironment (TME). Tumor‐associated …