This review focuses on the systemic complications of acromegaly. Mortality in this disease is
increased mostly because of cardiovascular and respiratory diseases, although currently …

Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting
pituitary adenoma and leads to acromegaly—a disorder of disproportionate skeletal, tissue …

Acromegaly is associated with an enhanced mortality, with cardiovascular and respiratory
complications representing not only the most frequent comorbidities but also two of the main …

AACE= American Association of Clinical Endocrinologists; BEL=“best evidence” level;
BMD= bone mineral density; CPAP= continuous positive airway pressure; CPG= clinical …

Acromegaly is caused by excess growth hormone (GH) secretion emanating from a
somatotroph adenoma. High GH and Insulin-like growth factor-1 (IGF-1) levels lead to acral …

Impaired cardiovascular function has recently been demonstrated to potentially reduce life
expectancy both in GH deficiency and excess. Experimental and clinical studies have …

Acromegaly is a rare disease caused by growth hormone hypersecretion, mostly from a
pituitary adenoma, driving insulin-like growth factor 1 overproduction. Manifestations include …

Even with modern treatment, acromegaly is associated with a 2-to 3-fold increase in
mortality, mainly from vascular disease, which is probably a result of the long exposure of …

Growth hormone (GH) is synthesised and secreted by the somatotroph cells of the anterior
lobe of the pituitary gland. Its actions involve multiple organs and systems, affecting …

Increased mortality from cardiovascular diseases has been reported in acromegaly. Our
objective was to evaluate the impact of glucose tolerance abnormalities and/or systemic …