IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the
cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti …

Insulin and insulin-like growth factors (IGFs) are well known as key regulators of energy
metabolism and growth. There is now considerable evidence that these hormones and the …

There is now extensive evidence that mammographic density is an independent risk factor
for breast cancer that is associated with large relative and attributable risks for the disease …

Preclinical evidence that targeting the insulin-like growth factor receptor (IGF-IR) is effective
in cancer treatment has been accumulating for almost two decades. Efforts to develop drugs …

Background: Greater weight and body mass index (BMI) are negatively correlated with
mammographic density, a strong risk factor for breast cancer, and are associated with an …

Background: Vitamin D status, determined on the basis of 25-hydroxyvitamin D [25 (OH) D]
concentrations, is associated with the risk of several diseases. Vitamin D binding protein …

Mammographic breast density is a strong risk factor for breast cancer but whether breast
density is a general marker of susceptibility or is specific to the location of the eventual …

Common chronic diseases of Western societies, such as coronary heart disease, diabetes
mellitus, cancer, hypertension, obesity, dementia, and allergic diseases are significantly …

Purpose: Mammographic density is a strong and highly heritable risk factor for breast
cancer. The purpose of this study was to examine the extent to which mammographic …

Over the last two decades, many studies have demonstrated that the insulin-like growth
factor-1 (IGF-1) is involved in a number of patho-physiological processes, as well as in the …