Somatic mutations in the TP53 gene are one of the most frequent alterations in human
cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which …

Despite decades of intense research, the complex biology of glioblastoma (GBM) is not
completely understood. Progression-free survival and overall survival have remained …

Summary Background Individuals with Li-Fraumeni syndrome have a high lifetime risk of
developing cancer. We assessed the feasibility and potential clinical effect of a …

In 1969, a remarkable cancer predisposition syndrome was reported by Li and Fraumeni.
Using a classical epidemiologic approach, they retrospectively evaluated 280 medical …

Germline pathogenic variants in TP53 gene have different consequences according to cell,
tissue, context and age. The occurrence of frequent variants in patients with no criteria …

In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …

Carriers of germline mutations in the TP53 gene, encoding the cell-cycle regulator and
tumour suppressor p53, have a markedly increased risk of cancer-related morbidity and …

The tumor suppressor gene TP53, encoding p53, is expressed as several transcripts. The
fully spliced p53 (FSp53) transcript encodes the canonical p53 protein. The alternatively …

Li‐Fraumeni syndrome (LFS) is a rare cancer predisposing condition caused by germline
mutations in TP 53, the gene encoding the TP 53 transcription factor. LFS is typified by the …

Three decades of p53 research have led to many advances in understanding the basic
biology of normal and cancer cells. Nonetheless, the detailed functions of p53 in normal …