Cytokines are major regulators of innate and adaptive immunity that enable cells of the
immune system to communicate over short distances. Cytokine therapy to activate the …

Cytokines that control the immune response were shown to have efficacy in preclinical
murine cancer models. Interferon (IFN)-α is approved for treatment of hairy cell leukemia …

Cancer immunotherapy is designed to stimulate the immune system to reject and destroy
tumors. Recently, interleukin-15 (IL-15), a member of the four α-helix bundle family of …

Antigen-specific CD8 T cells are central to the control of chronic infections and cancer, but
persistent antigen stimulation results in T cell exhaustion. Exhausted CD8 T cells have …

This review provides an in-depth description of the preclinical and clinical studies
demonstrating the effectiveness and limitations of IL-15 and IL-15 analogs given as an …

IL2 and IL15, members of the 4α-helix bundle family of cytokines, play pivotal roles in the
control of the life and death of lymphocytes. Although their heterotrimeric receptors have two …

Natural killer (NK) cells are important early responders against viral infections. Changes in
metabolism are crucial to fuel NK cell responses, and altered metabolism is linked to NK cell …

IL15, a potent stimulant of CD8+ T cells and natural killer (NK) cells, is a promising cancer
immunotherapeutic. ALT-803 is a complex of an IL15 superagonist mutant and a dimeric …

Purpose: The first-in-human clinical trial with human bolus intravenous infusion IL15 (rhIL15)
was limited by treatment-associated toxicity. Here, we report toxicity, immunomodulation …

The administration of cytokines that modulate endogenous or transferred T-cell immunity
could improve current approaches to clinical immunotherapy. Interleukin-2 (IL-2) is used …