Helicobacter pylori is a major human pathogen for which increasing antibiotic resistance
constitutes a serious threat to human health. Molecular mechanisms underlying this …

Helicobacter pylori is an important human pathogen that colonises the stomach of about half
of the world's population. The bacterium has now been accepted as the causative agent of …

Horizontal gene transfer (HGT) confers the rapid acquisition of novel traits and is pervasive
throughout microbial evolution. Despite the central role of HGT, the evolutionary forces that …

Understanding how evolution of antimicrobial resistance increases resistance to other drugs
is a challenge of profound importance. By combining experimental evolution and genome …

Helicobacter pylori, a human pathogen with a high global prevalence, is the causative
pathogen for multiple gastrointestinal diseases, especially chronic gastritis, peptic ulcers …

Horizontal gene transfer (HGT) is important for microbial evolution, yet we know little about
the fitness effects and dynamics of horizontally transferred genetic variants. In this study, we …

Nitazoxanide (NTZ) is a redox-active nitrothiazolyl-salicylamide prodrug that kills
Helicobacter pylori and also many anaerobic bacterial, protozoan, and helminthic species …

We developed a microarray hybridization–based method,'comparative genome
sequencing'(CGS), to find mutations in bacterial genomes and used it to study …

In this study, we systematically examined in vitro frequencies and spectra of the
spontaneous mutations in Helicobacter pylori that confer resistance to clarithromycin (Clar) …

Helicobacter pylori drug resistance presents a significant challenge to the successful
eradication of this pathogen. To find strategies to improve the eradication efficacy of H …