Abstract Purpose of Review The purpose of this review is to update the reader on the current
applications of platelet-rich plasma (PRP) in the treatment of knee osteoarthritis (KOA). This …

Concern that misinformation from direct-to-consumer marketing of largely unproven
“biologic” treatments such as platelet-rich plasma and cell-based therapies may erode the …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …

Background: A comprehensive approach to the evaluation of biologic therapies for
musculoskeletal conditions is required to guide appropriate future use. Clinical studies …

BACKGROUND: Regenerative medicine is a medical subspecialty that seeks to recruit and
enhance the body's own inherent healing armamentarium in the treatment of patient …

Background: Several cell-based therapies have been proposed in recent years the
management of low back pain, including the injection of medicinal signaling cells or …

BACKGROUND: The use of bone marrow concentrate (BMC) for treatment of
musculoskeletal disorders has become increasingly popular over the last several years, as …

Background: The lack of a standardized system for describing cell therapies acts as a barrier
to advancement in clinical and basic research and practice. The aim of this study was to …

There is good scientific rationale to support the use of growth factors to promote
musculoskeletal tissue regeneration. However, the clinical effectiveness of platelet-rich …

Human Microphysiological Systems (hMPS), otherwise known as organ-and tissue-on-a-
chip models, are an emerging technology with the potential to replace in vivo animal studies …