Neurotransmission between neurons, which can occur over the span of a few milliseconds,
relies on the controlled release of small molecule neurotransmitters, many of which are …

Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino
acid is:(i) A main precursor of extracellular collagens (the most abundant human proteins) …

The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with
low treatment efficacy. However, the field is dominated by underpowered studies focusing …

Abnormalities in functional connectivity between brain areas have been postulated as an
important pathophysiological mechanism underlying schizophrenia,. In particular …

Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …

Recent studies are beginning to paint a clear and consistent picture of the impairments in
psychological and cognitive competencies that are associated with microdeletions in …

With its hallucinations, delusions, thought disorder, and cognitive deficits, schizophrenia
affects the most basic human processes of perception, emotion, and judgment. Evidence …

Abstract Individuals with 22q11. 2 microdeletions show behavioral and cognitive deficits and
are at high risk of developing schizophrenia. We analyzed an engineered mouse strain …

In recent years, there have been huge advances in the use of genetically modified mice to
study pathophysiological mechanisms involved in schizophrenia. This has allowed rapid …

In humans, dopamine neurotransmission is influenced by functional polymorphisms in the
dopamine transporter (DAT 1) and catechol-O-methyltransferase (COMT) genes. Here, we …