Adverse effects of GLP-1 receptor agonists

TD Filippatos, TV Panagiotopoulou… - The review of diabetic …, 2015 - pmc.ncbi.nlm.nih.gov
Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of injective anti-diabetic
drugs that improve glycemic control and many other atherosclerosis-related parameters in …

Obesity and pancreatitis

B Khatua, B El-Kurdi, VP Singh - Current opinion in …, 2017 - journals.lww.com
We discuss how obesity may contribute to increasing acute pancreatitis incidence, the role
of lipolytic unsaturated fatty acid release in worsening acute pancreatitis, and potential …

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass

RK Mitchell, A Mondragon, L Chen… - Human molecular …, 2015 - academic.oup.com
Abstract Type 2 diabetes (T2D) is characterized by β cell dysfunction and loss. Single
nucleotide polymorphisms in the T-cell factor 7-like 2 (TCF7L2) gene, associated with T2D …

Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice

Y Li, M Bader, I Tamargo, V Rubovitch… - Journal of …, 2015 - Wiley Online Library
Traumatic brain injury (TBI), a brain dysfunction for which there is no present effective
treatment, is often caused by a concussive impact to the head and affects an estimated 1.7 …

Glucose levels show independent and dose-dependent association with worsening acute pancreatitis outcomes: Post-hoc analysis of a prospective, international …

A Nagy, MF Juhász, A Görbe, A Váradi, F Izbéki… - Pancreatology, 2021 - Elsevier
Background Metabolic risk factors, such as obesity, hypertension, and hyperlipidemia are
independent risk factors for the development of various complications in acute pancreatitis …

[HTML][HTML] Pancreas volume and fat deposition in diabetes and normal physiology: consideration of the interplay between endocrine and exocrine pancreas

Y Saisho - The review of diabetic studies: RDS, 2016 - ncbi.nlm.nih.gov
The pancreas is comprised of exocrine and endocrine components. Despite the fact that
they are derived from a common origin in utero, these two compartments are often studied …

Averrhoa carambola leaves prevent dyslipidemia and oxidative stress in a rat model of poloxamer-407-induced acute hyperlipidemia

MS Abduh, SAM Saghir, AM Al Hroob… - Frontiers in …, 2023 - frontiersin.org
Background: The star fruit [Averrhoa carambola L (Oxalidaceae)] is traditionally used in the
treatment of many ailments in many countries. It possesses several pharmacological …

Effect of nucleotides on growth performance, gut health, and some immunological parameters of broiler chicken exposed to high stocking density

NF Kamel, MM Hady, NM Ragaa, FF Mohamed - Livestock Science, 2021 - Elsevier
The current study was conducted to investigate the effect of dietary nucleotides inclusion
rate on growth performance, gut health, and immunity of broiler chickens exposed to high …

[HTML][HTML] Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

M Lucey, P Pickford, S Bitsi, J Minnion, J Ungewiss… - Molecular …, 2020 - Elsevier
Objective The objective of this study was to determine how pharmacokinetically
advantageous acylation impacts on glucagon-like peptide-1 receptor (GLP-1R) signal bias …

Endocrine system on chip for a diabetes treatment model

DTT Nguyen, D Van Noort, IK Jeong, S Park - Biofabrication, 2017 - iopscience.iop.org
The endocrine system is a collection of glands producing hormones which, among others,
regulates metabolism, growth and development. One important group of endocrine diseases …