The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of
functions in the body, including homeostasis, synthesis of essential components, nutrient …

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

The blood–brain barrier (BBB) represents a key challenge in developing brain-penetrating
therapeutic molecules. BBB dysfunction is also associated with the onset and progression of …

Cancer kills millions of individuals every year all over the world (Global Cancer
Observatory). The physiological and biomechanical processes underlying the tumor are still …

Plastic pollution has become a significant global problem over the years, leading to the
continuous decomposition and accumulation of micro/nanoplastics (MNPLs) in the …

The blood-brain barrier (BBB) is critical for the central nervous system, as its integrity
protects neurons and other brain cells from harmful toxicants and disease-associated …

Significant advancements in the field of preclinical in vitro blood-brain barrier (BBB) models
have been achieved in recent years, by developing monolayer-based culture systems …

Because of the brain's complexity, developing effective treatments for neurological disorders
is a formidable challenge. Research efforts to this end are advancing as in vitro systems …

Simple Summary This systematic review showed different therapeutic approaches to
glioblastoma on-a-chip with varying levels of complexity, answering, from the simplest …

Current available animal and in vitro cell-based models for studying brain-related
pathologies and drug evaluation face several limitations since they are unable to reproduce …