Abstract Lamivudine (3TC), the negative enantiomer of 2′-deoxy-3′-thiacytidine, is a
dideoxynucleoside analogue used in combination with other agents in the treatment of …

The kidney plays a major role in the elimination of drugs. The purpose of this paper is to:(i)
review the mechanisms of renal elimination;(ii) identify potential mechanisms for renal drug …

Nucleoside reverse transcriptase inhibitors (NRTIs) need to enter cells to act against the HIV-
1. Human organic cation transporters (hOCT1–3) are expressed and active in CD4+ T cells …

Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE)
testing for the approval of immediate release (IR) solid oral dosage forms containing …

Over the past three decades, the Isolated Perfused Rat Kidney (IPK) has been used to study
numerous aspects of renal drug disposition. Among the available ex-vivo methods to study …

A single‐center, open‐label, three‐way crossover study was conducted in 24 healthy
subjects to assess (1) the bioequivalence of a combined lamivudine 150 mg/zidovudine 300 …

Each year, 150 million outpatient prescriptions for antibiotics are dispensed in the United
States (1). In institutional settings, 25 to 35% of hospitalized patients receive antibiotic …

The purpose of this parallel treatment group, double-blind. multicenter study was to
lharacterize the pharmacokinetics of nevirapine and lamivudine when coadministered to …

ABSTRACT Cefdinir (Omnicef; Abbott Laboratories) is a cephalosporin antibiotic primarily
eliminated by the kidney. Nonlinear renal elimination of cefdinir has been previously …

Objective: To study the renal excretion and kidney accumulation of pentamidine, a
potentially nephrotoxic compound, in the isolated perfused rat kidney (IPK). Materials and …