Participation of glutamatergic ionotropic receptors in excitotoxicity: the neuroprotective role of prolactin

V Rodriguez-Chavez, J Moran, G Molina-Salinas… - Neuroscience, 2021 - Elsevier
Glutamate (Glu) is known as the main excitatory neurotransmitter in the central nervous
system. It can trigger a series of processes ranging from synaptic plasticity to …

[HTML][HTML] Growth hormone (GH) and gonadotropin-releasing hormone (GnRH) in the central nervous system: A potential neurological combinatory therapy?

CG Martínez-Moreno, D Calderón-Vallejo… - International Journal of …, 2018 - mdpi.com
This brief review of the neurological effects of growth hormone (GH) and gonadotropin-
releasing hormone (GnRH) in the brain, particularly in the cerebral cortex, hypothalamus …

[HTML][HTML] Neuroprotective peptides in retinal disease

D Cervia, E Catalani, G Casini - Journal of clinical medicine, 2019 - mdpi.com
In the pathogenesis of many disorders, neuronal death plays a key role. It is now assumed
that neurodegeneration is caused by multiple and somewhat converging/overlapping death …

[HTML][HTML] KLF13 Regulates the Activity of the GH-Induced JAK/STAT Signaling by Targeting Genes Involved in the Pathway

J Ávila-Mendoza, K Delgado-Rueda… - International Journal of …, 2023 - mdpi.com
The Krüppel-like factor 13 (KLF13) has emerged as an important transcription factor
involved in essential processes of the central nervous system (CNS). It predominantly …

Protective effects of agonists of growth hormone-releasing hormone (GHRH) in early experimental diabetic retinopathy

MC Thounaojam, FL Powell, S Patel… - Proceedings of the …, 2017 - National Acad Sciences
The potential therapeutic effects of agonistic analogs of growth hormone-releasing hormone
(GHRH) and their mechanism of action were investigated in diabetic retinopathy (DR) …

Growth hormone protects against kainate excitotoxicity and induces BDNF and NT3 expression in chicken neuroretinal cells

CG Martinez-Moreno, T Fleming, M Carranza… - Experimental Eye …, 2018 - Elsevier
There is increasing evidence to suggest a beneficial neuroprotective effect of growth
hormone (GH) in the nervous system. While our previous studies have largely focused on …

Growth hormone (GH) enhances endogenous mechanisms of neuroprotection and neuroplasticity after oxygen and glucose deprivation injury (OGD) and …

JD Olivares-Hernández, JE Balderas-Márquez… - Neural …, 2021 - Wiley Online Library
As a classical growth promoter and metabolic regulator, growth hormone (GH) is involved in
development of the central nervous system (CNS). This hormone might also act as a …

[HTML][HTML] Neuroprotective and Regenerative Effects of Growth Hormone (GH) in the Embryonic Chicken Cerebral Pallium Exposed to Hypoxic–Ischemic (HI) Injury

JD Olivares-Hernández, M Carranza… - International Journal of …, 2022 - mdpi.com
Prenatal hypoxic–ischemic (HI) injury inflicts severe damage on the developing brain
provoked by a pathophysiological response that leads to neural structural lesions, synaptic …

Agonist of growth hormone–releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury

LP Cen, TK Ng, JJ Liang, C Xu… - Proceedings of the …, 2021 - National Acad Sciences
Optic neuropathies are leading causes of irreversible visual impairment and blindness,
currently affecting more than 100 million people worldwide. Glaucoma is a group of optic …

[HTML][HTML] Regenerative effect of growth hormone (GH) in the retina after kainic acid excitotoxic damage

CG Martinez-Moreno, D Epardo… - International Journal of …, 2019 - mdpi.com
In addition to its role as an endocrine messenger, growth hormone (GH) also acts as a
neurotrophic factor in the central nervous system (CNS), whose effects are involved in …