Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder characterized by
chronic hyperglycemia and an inadequate response to circulatory insulin by peripheral …

Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a
disease that currently affects∼ 8% of the adult population worldwide. Pancreatic beta-cell …

Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Mitochondria are a quantitatively relevant source of reactive oxygen species (ROS) in the
majority of cell types. Here we review the sources and metabolism of ROS in this organelle …

The mitochondrion is at the core of cellular energy metabolism, being the site of most ATP
generation. Calcium is a key regulator of mitochondrial function and acts at several levels …

In addition to the well-established role of the mitochondria in energy metabolism, regulation
of cell death has recently emerged as a second major function of these organelles. This, in …

Oxidative stress is considered a major contributor to etiology of both “normal” senescence
and severe pathologies with serious public health implications. Mitochondria generate …

Cancer is an everyday medical concern which requires an appropriate treatment strategy.
The malfunction of cell cycle is a well-established cause for cancer induction. Chemotherapy …

In addition to the established role of the mitochondria in energy metabolism, regulation of
cell death has emerged as a second major function of these organelles. This seems to be …

The integrity of mitochondrial function is fundamental to cell life. It follows that disturbances
of mitochondrial function will lead to disruption of cell function, expressed as disease or …