Objective To understand belief in a specific scientific claim by studying the pattern of
citations among papers stating it. Design A complete citation network was constructed from …

The cellular prion protein (PrPC) is subjected to various processing under physiological and
pathological conditions, of which the α-cleavage within the central hydrophobic domain not …

Prion diseases are fatal brain disorders characterized by deposition of insoluble isoforms of
the prion protein (PrP). The normal and pathogenic structures of PrP are relatively well …

Prion diseases are incurable neurodegenerative disorders in which the normal cellular prion
protein (PrPC) converts into a misfolded isoform (PrPSc) with unique biochemical and …

Background Prionopathies are characterized by spongiform brain degeneration, myoclonia,
dementia, and periodic electroencephalographic (EEG) disturbances. The hallmark of …

It is now well established that the conversion of the cellular prion protein, PrPC, into its
anomalous conformer, PrPSc, is central to the onset of prion disease. However, both the …

The neurotoxic forms of the prion protein (PrP) that cause neurodegeneration in prion
diseases remain to be conclusively identified. Considerable evidence points to the …

The ubiquitously expressed cellular prion protein (PrP C) is subjected to the physiological α-
cleavage at a region critical for both PrP toxicity and the conversion of PrP C to its …

The physiological role of the cellular prion protein (PrPc) is still not fully understood. Current
evidence strongly suggests that PrPc overexpression in different cell lines sensitizes cells to …

Paul Brown, MD There is no shortage of recent reviews on various aspects of transmissible
spongiform encephalopathy (TSE), 1-12 but none has been addressed to clinical …