Development in the concept of bacterial polysaccharide repeating unit-based antibacterial conjugate vaccines

R Rohokale, Z Guo - ACS infectious diseases, 2023 - ACS Publications
The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx.
The complex glycans in the glycocalyx are involved in various biological events, such as …

Internal affairs: investigating the Brucella intracellular lifestyle

K von Bargen, JP Gorvel… - FEMS microbiology …, 2012 - academic.oup.com
Bacteria of the genus Brucella are Gram-negative pathogens of several animal species that
cause a zoonotic disease in humans known as brucellosis or Malta fever. Within their hosts …

Molecular insights into bacteroid development during Rhizobium–legume symbiosis

AF Haag, MFF Arnold, KK Myka… - FEMS microbiology …, 2013 - academic.oup.com
Rhizobial soil bacteria can form a symbiosis with legumes in which the bacteria fix
atmospheric nitrogen into ammonia that can be utilized by the host. The plant, in turn …

Progress in Brucella vaccine development

X Yang, JA Skyberg, L Cao, B Clapp, T Thornburg… - Frontiers in biology, 2013 - Springer
Brucella spp. are zoonotic, facultative intracellular pathogens, which cause animal and
human disease. Animal disease results in abortion of fetuses; in humans, it manifests flu-like …

Glucans and applications in drug delivery

H Lin, R Han, W Wu - Carbohydrate Polymers, 2024 - Elsevier
Glucan is a natural polysaccharide widely distributed in cereals and microorganisms that
has various biological activities, including immunomodulatory, anti-infective, anti …

Brucellosis vaccines for livestock

ZI Goodwin, DW Pascual - Veterinary immunology and immunopathology, 2016 - Elsevier
Brucellosis is a livestock disease responsible for fetal loss due to abortions. Worldwide, this
disease has profound economic and social impact by reducing the ability of livestock …

Idiosyncratic biogenesis of intracellular pathogens-containing vacuoles

B Vaughn, Y Abu Kwaik - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
While most bacterial species taken up by macrophages are degraded through processing of
the bacteria-containing vacuole through the endosomal-lysosomal degradation pathway …

Functional and structural analysis of a cyclization domain in a cyclic β-1, 2-glucan synthase

N Tanaka, R Saito, K Kobayashi, H Nakai… - Applied Microbiology …, 2024 - Springer
Abstract Cyclic β-1, 2-glucan synthase (CGS) is a key enzyme in production of cyclic β-1, 2-
glucans (CβGs) which are involved in bacterial infection or symbiosis to host organisms …

Brucella melitensis Wzm/Wzt System: Changes in the Bacterial Envelope Lead to Improved Rev1Δwzm Vaccine Properties

S Mena-Bueno, I Poveda-Urkixo, O Irazoki… - Frontiers in …, 2022 - frontiersin.org
The lipopolysaccharide (LPS) O-polysaccharide (O-PS) is the main virulence factor in
Brucella. After synthesis in the cytoplasmic membrane, O-PS is exported to the periplasm by …

Host-Brucella interactions and the Brucella genome as tools for subunit antigen discovery and immunization against brucellosis

G Gomez, LG Adams, A Rice-Ficht… - Frontiers in cellular and …, 2013 - frontiersin.org
Vaccination is the most important approach to counteract infectious diseases. Thus, the
development of new and improved vaccines for existing, emerging, and re-emerging …