ABSTRACT A recent Perspective article described the “carbohydrate-insulin model (CIM)” of
obesity, asserting that it “better reflects knowledge on the biology of weight control” as …

Evidence from observational studies and randomized trials suggests that prediabetes and
type 2 diabetes mellitus (T2DM) can develop in genetically susceptible individuals in …

The prevalence of obesity, measured by body mass index, has risen to unacceptable levels
in both men and women in the United States and worldwide with resultant hazardous health …

Polycystic ovary syndrome (PCOS) is a common condition affecting reproductive-aged
women with reproductive, metabolic and psychological consequences. Weight and lifestyle …

Robert is a 47-year-old patient who initially weighed 120 kilograms. He lost 40 kilograms 3
years ago by carefully following your guidance to decrease his caloric intake to 1500 …

Aims/hypothesis Weight reduction is fundamental for type 2 diabetes management and
remission, but uncertainty exists over which diet type is best to achieve and maintain weight …

The obesity pandemic continues unabated despite a persistent public health campaign to
decrease energy intake (“eat less”) and increase energy expenditure (“move more”). One …

Large prospective cohort studies consistently show associations of a high dietary fiber intake
(> 25 g/d in women and> 38 g/d in men) with a 20–30% reduced risk of developing type 2 …

Obesity is a chronic metabolic disease characterised by an increase of body fat stores. It is a
gateway to ill health, and it has become one of the leading causes of disability and death …

Despite intensive research, the causes of the obesity epidemic remain incompletely
understood and conventional calorie-restricted diets continue to lack long-term efficacy …