[HTML][HTML] Discovery and development of safe-in-man broad-spectrum antiviral agents
PI Andersen, A Ianevski, H Lysvand… - International Journal of …, 2020 - Elsevier
Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-
specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases …
specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases …
Medicinal plants: Treasure for antiviral drug discovery
The pandemic of viral diseases like novel coronavirus (2019‐nCoV) prompted the scientific
world to examine antiviral bioactive compounds rather than nucleic acid analogous …
world to examine antiviral bioactive compounds rather than nucleic acid analogous …
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
R Xiong, L Zhang, S Li, Y Sun, M Ding, Y Wang… - Protein & …, 2020 - academic.oup.com
Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics
worldwide, such as the on-going outbreak of the novel coronavirus SARS-CoV-2. Herein, we …
worldwide, such as the on-going outbreak of the novel coronavirus SARS-CoV-2. Herein, we …
[HTML][HTML] Potential antiviral options against SARS-CoV-2 infection
A Ianevski, R Yao, MH Fenstad, S Biza, E Zusinaite… - Viruses, 2020 - mdpi.com
As of June 2020, the number of people infected with severe acute respiratory coronavirus 2
(SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the …
(SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the …
[HTML][HTML] Identification and tracking of antiviral drug combinations
Combination therapies have become a standard for the treatment for HIV and hepatitis C
virus (HCV) infections. They are advantageous over monotherapies due to better efficacy …
virus (HCV) infections. They are advantageous over monotherapies due to better efficacy …
[HTML][HTML] Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine
PI Andersen, K Krpina, A Ianevski, N Shtaida, E Jo… - Viruses, 2019 - mdpi.com
Viruses are the major causes of acute and chronic infectious diseases in the world.
According to the World Health Organization, there is an urgent need for better control of viral …
According to the World Health Organization, there is an urgent need for better control of viral …
[HTML][HTML] Synergistic interferon-alpha-based combinations for treatment of SARS-CoV-2 and other viral infections
A Ianevski, R Yao, E Zusinaite, LS Lello, S Wang, E Jo… - Viruses, 2021 - mdpi.com
Background: There is an urgent need for new antivirals with powerful therapeutic potential
and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons …
and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons …
Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including …
R Xiong, L Zhang, S Li, Y Sun, M Ding, Y Wang, Y Zhao… - BioRxiv, 2020 - biorxiv.org
Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics
worldwide, such as the on-going outbreak of coronavirus SARS-CoV-2. Existing direct …
worldwide, such as the on-going outbreak of coronavirus SARS-CoV-2. Existing direct …
[HTML][HTML] A roadmap to engineering antiviral natural products synthesis in microbes
Natural products continue to be the inspirations for us to discover and acquire new drugs.
The seemingly unstoppable viruses have kept records high to threaten human health and …
The seemingly unstoppable viruses have kept records high to threaten human health and …
[HTML][HTML] The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus …
Enteroviruses are a significant global health concern, causing a spectrum of diseases from
the common cold to more severe conditions like hand-foot-and-mouth disease, meningitis …
the common cold to more severe conditions like hand-foot-and-mouth disease, meningitis …