Gene therapy provides a promising approach in treating cancers with high efficacy and
selectivity and few adverse effects. Currently, the development of functional vectors with …

Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

Using nanoparticles to deliver drugs to cells has the potential to revolutionize the treatment
of many diseases, including HIV, cancer, and diabetes. One of the major challenges facing …

After more than 20 years of intensive investigations, gene therapy has become one of the
most promising strategies for treating genetic diseases. However, the lack of ideal delivery …

The era of nucleic acid nanomedicine has arrived, as evidenced by Patisiran, a small
interfering RNA (siRNA) encapsulated lipid nanoparticle (LNP), and mRNA-loaded LNPs …

Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains
challenging, with low yields and low full: empty capsid ratios in the harvest. To elucidate the …

Polymeric carriers have emerged as major non-viral alternatives for gene delivery due to
their lower immunogenicity and pathogenicity. However, during intracellular delivery of …

Cell delivery reagents often exploit the endocytic pathway as a route of cell entry. Once
endocytosed, these reagents must overcome endosomal entrapment to ensure the release …

Chemical vectors for non-viral gene delivery are based on engineered DNA nanoparticles
produced with various range of macromolecules suitable to mimic some viral functions …