Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms

A Inserra, D De Gregorio, G Gobbi - Pharmacological Reviews, 2021 - ASPET
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Assessing the risk–benefit profile of classical psychedelics: A clinical review of second-wave psychedelic research

D Bender, DJ Hellerstein - Psychopharmacology, 2022 - Springer
Rationale A broad reassessment of the potential benefits of psychedelic drugs has led to the
initiation of multiple major clinical trials in an effort to advance their status to become FDA …

The subjective effects of psychedelics are necessary for their enduring therapeutic effects

DB Yaden, RR Griffiths - ACS Pharmacology & Translational …, 2020 - ACS Publications
Classic psychedelics produce altered states of consciousness that individuals often interpret
as meaningful experiences. Across a number of human studies, when the participant-rated …

Effects of psilocybin-assisted therapy on major depressive disorder: a randomized clinical trial

AK Davis, FS Barrett, DG May, MP Cosimano… - JAMA …, 2021 - jamanetwork.com
Importance Major depressive disorder (MDD) is a substantial public health burden, but
current treatments have limited effectiveness and adherence. Recent evidence suggests that …

[图书][B] Philosophy of psychedelics

C Letheby - 2021 - books.google.com
Recent clinical trials show that psychedelics such as LSD and psilocybin can be given safely
in controlled conditions, and can cause lasting psychological benefits with one or two …

Validation of the Psychological Insight Scale: A new scale to assess psychological insight following a psychedelic experience

JM Peill, KE Trinci, H Kettner… - Journal of …, 2022 - journals.sagepub.com
Introduction: As their name suggests,'psychedelic'(mind-revealing) compounds are thought
to catalyse processes of psychological insight; however, few satisfactory scales exist to …

Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences

RJ Zeifman, H Kettner, BA Pagni, A Mallard… - Scientific reports, 2023 - nature.com
Psilocybin and lysergic acid diethylamide (LSD) experiences can range from very positive to
highly challenging (eg, fear, grief, and paranoia). These challenging experiences contribute …

Psychedelics and health behaviour change

PJ Teixeira, MW Johnson… - Journal of …, 2022 - journals.sagepub.com
Healthful behaviours such as maintaining a balanced diet, being physically active and
refraining from smoking have major impacts on the risk of developing cancer, diabetes …

Effects of naturalistic psychedelic use on depression, anxiety, and well-being: associations with patterns of use, reported harms, and transformative mental states

CL Raison, R Jain, AD Penn, SP Cole, S Jain - Frontiers in Psychiatry, 2022 - frontiersin.org
Survey-based studies suggest naturalistic psychedelic use provides mental health benefits
similar to those observed in clinical trials. The current study sought to confirm these findings …

Post-psychedelic reductions in experiential avoidance are associated with decreases in depression severity and suicidal ideation

RJ Zeifman, AC Wagner, R Watts, H Kettner… - Frontiers in …, 2020 - frontiersin.org
Psychedelic therapy shows promise as a novel intervention for a wide range of mental
health concerns but its therapeutic action is incompletely understood. In line with …